Author

Jaakko Mattila

University of HelsinkiORCID 0000-0002-4064-2791Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 4 Organism:Drosophila· 4 Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2

Frequent Co-Authors

Onur DeniziD· 3 shared Ville HietakangasiD· 3 shared Kateryna GaertneriD· 2 shared Tuuli KirkineniD· 2 shared Arathi Preeth Babu· 1 shared Cornelia Biehler· 1 shared Jenny Barlund· 1 shared Konstantin KoganiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersPhysiology

Onur DenizORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Nutrient-responsive midgut turnover is spatially controlled by serotonin signaling

Nicole Lamichane, Petteri Borgman, Terhi Rintakangas, Kateryna Gaertner, Marius Robciuc, Onur Deniz, Tuuli Kirkinen, Cornelia Biehler, Simon Andersson, Jenny Barlund, Oona Kinnunen, Pekka Katajisto, Jaakko Mattila, Ville Hietakangas

The paper shows serotonin signaling spatially controls nutrient-responsive midgut turnover in Drosophila by regulating enteroblast maturation and morphological changes through the 5HT7 receptor.

bioRxiv · Nov 4, 2026 · PreprintPhysiology

Spalt-related is an integrated stress response-activated inhibitor of mTORC1-mediated growth

Onur Deniz, Liu Y, Tuuli Kirkinen, Krista Kokki, Kateryna Gaertner, Pau Clavell-Revelles, Jaakko Mattila, Ville Hietakangas

This study identifies Spalt-related (Salr) as a negative regulator of growth and lipid storage, activated through the integrated stress response and converging with FoxO to promote catabolism during nutrient stress.

The EMBO Journal · Jul 11, 2026Peer-reviewedCell Biology

Nuclear Factor Y controls epithelial growth by regulating mTOR in the Drosophila midgut

Tetiana R. Strutynska, Onur Deniz, Jaakko Mattila

This study shows that NF-Y regulates mTORC1 activity in Drosophila midgut ISC to control epithelial growth under nutrient-rich conditions.

bioRxiv · Feb 2, 2026 · PreprintPhysiology

Apical actin filament turnover mediated by cyclase-associated protein is required for organization of non-centrosomal microtubules in epithelium

Arathi Preeth Babu, Sachin Muralidharan, Konstantin Kogan, Tommi Kotila, Ville Hietakangas, Jaakko Mattila, Minna Poukkula

This study shows that CAP-mediated apical actin turnover is necessary for proper non-centrosomal microtubule organization in Drosophila epithelial cells, affecting nuclear positioning and cargo transport.

bioRxiv · Sep 12, 2025 · PreprintCell Biology