Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma
James M. Stafford, Chul‐Hwan Lee, Philipp Voigt, Nicolas Descostes, Ricardo Saldaña-Meyer, Jia-Ray Yu, Gary LeRoy, Ozgur Oksuz, Jessica R. Chapman, Fernando Suarez, Aram Sandaldjian Modrek, Nermin Sumru Bayin, Dimitris G. Placantonakis, Matthias A. Karajannis, Matija Snuderl, , Danny Reinberg
The paper investigates how H3K27M mutations inhibit PRC2 in DIPG, revealing mechanisms of chromatin alteration and PRC2 dysfunction.
Science Advances · Oct 5, 2018Peer-reviewedMolecular Biology