Author

Özlem Altıntaş

ETH ZurichORCID 0000-0002-4121-7199Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Michael Robert MacArthuriD· 2 shared Sarah Jayne MitchelliD· 2 shared Amandeep BajwaiD· 1 shared Arthur G. CentenoiD· 1 shared Charlotte G. ManniD· 1 shared Coleen Tara MurphyiD· 1 shared Collin Y. EwaldiD· 1 shared Danny ArendsiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersPhysiology

Michael Robert MacArthurORCID

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2 papers

Recent·Most cited

Pharmacologic AMPK Activation Extends Lifespan in C. elegans and Improves Aspects of Healthspan in Mice

Özlem Altıntaş, Marie Knufinke, Charlotte G. Mann, P. Kent Langston, Joshua D. Rabinowitz, Coleen Tara Murphy, Collin Y. Ewald, Sarah Jayne Mitchell, Michael Robert MacArthur

This study shows that pharmacologic AMPK activation with MK-8722 extends lifespan in C. elegans and improves metabolic health in aged mice.

bioRxiv · Apr 29, 2026 · PreprintPhysiology

Genetic Modulation of Lifespan: Dynamic Effects, Sex Differences, and Body Weight Trade-offs

Danny Arends, David George Ashbrook, Suheeta Roy, Lu Lu, Zachary Sloan, Arthur G. Centeno, Kurt H. Lamour, João Pedro de Magalhães, Pjotr Prins, Karl W. Broman, Śaunak Sen, Sarah Jayne Mitchell, Michael Robert MacArthur, Özlem Altıntaş, Xiaoxu Li, , Robert W. Williams

This study identifies genetic loci affecting lifespan dynamics, sex differences, and body weight trade-offs in mice using an actuarial approach.

Nature · Apr 22, 2026Peer-reviewedGenetics