Karin Giller

Bilayer-bound structure of SARS-CoV-2 Envelope protein in complex with a host PDZ domain

This study determines the bilayer-bound structure of SARS-CoV-2 E protein in complex with a host PDZ domain, revealing its pentameric oligomer state and structural interactions.

A Heart Disease-Associated TSPO Variant Alters Transmembrane Helix Dynamics

The paper investigates how a disease-associated TSPO variant affects transmembrane helix dynamics using solution NMR spectroscopy.

The clinical drug candidate anle138b binds predominantly to the central cavity in lipidic Aβ fibrils and modulates fibril formation.

This paper shows that anle138b binds to a cavity in lipidic Aβ fibrils and reduces fibril formation by 75%, suggesting a potential therapeutic mechanism for Alzheimer's disease.

Mechanism of sensor kinase CitA transmembrane signaling

The paper investigates the transmembrane signaling mechanism of the CitA histidine kinase using structural biology techniques and shows how structural changes in the sensor domain are transmitted across the membrane.

Cryo-EM structures of lipidic fibrils of amyloid-β (1-40)

The paper determines the structure of amyloid-β (Aβ40) fibrils bound to lipids using cryo-EM, showing lipid binding and potential relevance to Alzheimer's disease pathogenesis.