J. Francisco Nistal

ATG4D loss leads to late-onset cardiomyopathy and stress-induced heart failure in mice, and its repression marks maladaptive cardiac remodeling in humans

This study shows that ATG4D deficiency in mice causes late-onset cardiomyopathy and stress-induced heart failure, and ATG4D repression is linked to human cardiac remodeling.

Integrated Stress Response Triggered by Excessive Glycosylation Drives Thoracic Aortic aneurysm

This study identifies the HBP-ISR axis as a driver of thoracic aortic aneurysm in Marfan Syndrome, showing that targeting this pathway can reverse aortic dilation in mice and is associated with human TAAD.