Matthew B. Smith

NuclearIDTracker resolves intestinal cell identity and lineage dynamics through nuclear phenotypic signatures

NuclearIDTracker uses nuclear phenotypic signatures to classify intestinal cell types and track lineage dynamics without fluorescent reporters.

UDIST: unsupervised disentanglement of shape and texture for multi-scale phenotypic profiling in 2D microscopy

UDIST separates shape and texture in microscopy images into independent latent subspaces, enabling unbiased phenotypic analysis across biological scales.

Personalized multi-assay profiling of respiratory motile ciliopathies and mRNA therapy

This study develops a personalized multi-assay platform using nasal epithelial cells to assess ciliary function and therapeutic response in primary ciliary dyskinesia.

Cryo-electron tomography reveals the nanoscale architecture of the actin cortex in cellular blebs

This study uses cryo-ET to reveal the nanoscale 3D organization of cortical actin in cellular blebs, showing short and straight actin filaments and structural parameters.

Active mesh and neural network pipeline for cell aggregate segmentation

The paper introduces a segmentation pipeline combining neural networks and active meshes to segment and track cells in 3D time-lapse images of organoids and stem cells.

Signalling-dependent refinement of cell fate choice during tissue remodelling

The paper investigates how signalling networks and tissue flows interact during vein refinement in Drosophila pupal wings, showing that cell fate adjustments, not large-scale flows, drive precise patterning.

ECM remodeling and spatial cell cycle coordination determine tissue growth kinetics

The paper shows that tissue growth in Drosophila abdomen stops due to rapid cell cycle arrest, not gradual slowing, and that ECM remodeling is required for expansion.