Author

Nieske Brouwer

University Medical Center Groningen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Neuroscience· 6

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 6 Research Focus:differential expression· 6 Approach:statistical model· 6 Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:human· 4 Organism:mouse· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

Bart J. L. EggeniD· 6 shared Susanne M. KooistraiD· 5 shared Laura KrachtiD· 4 shared Emma GerritsiD· 3 shared H. W. G. M. BoddekeiD· 3 shared Anneke MiedemaiD· 2 shared Evelyn M. Wesseling· 2 shared Marissa Lisa DubbelaariD· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersNeuroscience

Bart J. L. EggenORCID

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Radiotherapy induces persistent innate immune reprogramming of microglia into a primed state

Daniëlle C. Voshart, Takuya Oshima, Yuting Jiang, Gideon P. van der Linden, Anna P. Ainslie, Luiza Reali Nazario, Fleur van Buuren-Broek, Ayla C. Scholma, Hilmar R. J. van Weering, Nieske Brouwer, Jeffrey Sewdihal, Uilke Brouwer, Robert Paul Coppes, Inge R. Holtman, Bart J. L. Eggen, , Lara Barazzuol

This study shows that radiotherapy primes microglia in rats to have a heightened immune response to future inflammation, and this effect is observed in human brain tissue.

Cell Reports · Feb 1, 2024Peer-reviewedNeuroscience

Early-life stress lastingly impacts microglial transcriptome and function under basal and immune-challenged conditions

Kitty Reemst, Laura Kracht, Janssen M. Kotah, Reza Rahimian, Astrid A.S. van Irsen, Gonzalo Congains Sotomayor, Laura N. Verboon, Nieske Brouwer, Sophie Simard, Gustavo Turecki, Naguib Mechawar, Susanne M. Kooistra, Bart J. L. Eggen, Anikó Kőrösi

This study shows that early-life stress alters microglial transcriptome and function in mice, affecting phagocytic capacity and gene expression in adulthood.

Translational Psychiatry · Dec 8, 2022Peer-reviewedNeuroscience

Epigenetic regulation of innate immune memory in microglia

Xiaoming Zhang, Laura Kracht, Antônio Marcondes Lerário, Marissa Lisa Dubbelaar, Nieske Brouwer, Evelyn M. Wesseling, Erik Boddeke, Bart J. L. Eggen, Susanne M. Kooistra

The paper investigates how epigenetic changes in microglia influence their response to inflammatory and genotoxic stress, identifying distinct gene networks and functional phenotypes.

Journal of Neuroinflammation · May 14, 2022Peer-reviewedNeuroscience

Brain macrophages acquire distinct transcriptomes prior to demyelination in multiple sclerosis

Anneke Miedema, Emma Gerrits, Nieske Brouwer, Qiong Jiang, Laura Kracht, Michel Meijer, Erik Nutma, Regina M. B. Peferoen-Baert, Anna T. E. Pijnacker, Evelyn M. Wesseling, Marion H. C. Wijering, Hans‐Joachim Gabius, Sandra Amor, Bart J. L. Eggen, Susanne M. Kooistra

The paper identifies early transcriptomic changes in brain macrophages in MS tissue, linking them to lesion development and suggesting potential therapeutic targets.

bioRxiv · Oct 27, 2021 · PreprintNeuroscience

Profiling microglia from AD donors and non-demented elderly in acute human post-mortem cortical tissue

Astrid M. Alsema, Qiong Jiang, Laura Kracht, Emma Gerrits, Marissa Lisa Dubbelaar, Anneke Miedema, Nieske Brouwer, Elly M. Hol, Jinte Middeldorp, Roland E. van Dijk, Maya E. Woodbury, Astrid Wachter, Hualin Simon Xi, Thomas Möller, Knut Biber, , Bart J. L. Eggen

The paper profiles microglia transcriptomes in AD donors and non-demented elderly using bulk and single-cell RNA sequencing, finding no significant differences in gene expression or subcluster composition.

Frontiers in Molecular Neuroscience · Oct 28, 2020Peer-reviewedNeuroscience

Distinct gene expression profiles in leukocortical demyelinated white and grey matter areas of Multiple Sclerosis patients

Thecla A. van Wageningen, Emma Gerrits, A. Geleijnse, Nieske Brouwer, Jeroen J.G. Geurts, Bart J. L. Eggen, H. W. G. M. Boddeke, A.-M. van Dam

The paper compares gene expression profiles of demyelinated white and grey matter in MS patients, finding minimal overlap and distinct glial cell signatures.

bioRxiv · Jun 3, 2020 · PreprintNeuroscience