Author

David Scholten

Northwestern UniversityORCID 0000-0002-4604-1620Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Assay:flow cytometry· 2 Assay:imaging· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Huiping LiuiD· 3 shared Clive Henry WasserfalliD· 2 shared Deyu FangiD· 2 shared Fangjia Tong· 2 shared Hannah Faisal AlmubarakiD· 2 shared Leonidas C. PlataniasiD· 2 shared Massimo CristofanilliiD· 2 shared William John GradishariD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Huiping LiuORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

AI-enabled Spatial Profiling of Circulating Tumor-Immune Ecosystems Predicts Patient Outcomes Across Cancers

Joshua R Squires, Yuanfei Sun, Andrew Hoffmann, Youbin Zhang, Hao Pan, Fangjia Tong, Yiwen He, David Scholten, Hannah Faisal Almubarak, Michael J. Gurley, Allegra C. Minor, Anmol Singh, James Zhang, Hannah Ding, Chengsheng Mao, , Huiping Liu

The paper develops an AI framework to analyze blood scans and predict patient outcomes by characterizing tumor-immune ecosystems in circulation.

bioRxiv · Jul 3, 2026 · PreprintCancer Biology

Rare Subset of T Cells Form Heterotypic Clusters with Circulating Tumor Cells to Foster Cancer Metastasis

David Scholten, Lamiaa El-Shennawy, Yuzhi Jia, Youbin Zhang, Elizabeth Hyun, Carolina Reduzzi, Andrew Daniel Hoffmann, Hannah Faisal Almubarak, Fangjia Tong, Nurmaa Khund Dashzeveg, Yuanfei Sun, Joshua R. Squires, Janice Lu, Leonidas C. Platanias, Clive Henry Wasserfall, , Huiping Liu

The paper identifies a rare subset of CD4 and CD8 double positive T cells that form clusters with circulating tumor cells, promoting cancer metastasis through immune suppression and integrin-mediated interactions.

bioRxiv · Apr 1, 2025 · PreprintCancer Biology

Timing anti-PD-L1 checkpoint blockade immunotherapy to enhance tumor irradiation

Seung Young Lee, Joanna Pagacz, Sera Averbek, David Scholten, Yue Liu, Stephen J. Kron

This study shows that timing anti-PD-L1 therapy after radiation enhances tumor response by preventing CTL depletion and improving PD-L1 blockade.

Cancers · Jan 24, 2025Peer-reviewedCancer Biology

Robust collection and processing for label-free single voxel proteomics

Reta Birhanu Kitata, Marija Veličković, Zhangyang Xu, Rui Zhao, David Scholten, Rosalie Chu, Danny Orton, William Chrisler, Tong Zhang, Jeremy Abraham Mathews, Benjamin M. Bumgarner, Demirkan Besim Gursel, Ronald Jay Moore, Paul Piehowski, Tao Liu, , Tujin Shi

This paper introduces a method for label-free single voxel proteomics using wcSOP, enabling spatial resolution of protein expression in tissue samples.

Nature Communications · Jan 13, 2025Peer-reviewedMolecular Biology