The paper introduces a two-phase model of ageing using Smurfness to distinguish chronological age effects from biological age effects in transcriptional data.

Aging Cell · Oct 12, 2023Peer-reviewedSystems Biology

The ribose methylation enzyme FTSJ1 has a conserved role in neuron morphology and learning performance

Mira Brazane, Dilyana G. Dimitrova, Julien Pigeon, Chiara Paolantoni, Tao Ye, Virginie Marchand, Bruno Da Silva, Élise Schaefer, Margarita T. Angelova, Zornitza Stark, Martin Bruce Delatycki, Tracy Dudding‐Byth, Jozef Gécz, Pierre-Yves Plaçais, Laure Teysset, , Clément Carré

The paper identifies a novel FTSJ1 pathogenic variant and shows its role in neuron morphology and learning performance through RiboMethSeq and transcriptome analysis in human and Drosophila models.

Life Science Alliance · Jan 31, 2023Peer-reviewedMolecular Biology

tRNA 2-O-methylation modulates small RNA silencing and life span in Drosophila.

Margarita T. Angelova, Dilyana G. Dimitrova, Bruno Da Silva, Virginie Marchand, Caroline Jacquier, Cyrinne Achour, Mira Brazane, Catherine Goyenvalle, Valérie Bourguignon‐Igel, Salman Shehzada, Souraya Khouider, Tina Lenče, Vincent Guérineau, Jean‐Yves Roignant, Christophe Antoniewski, , Clément Carré

This study identifies two tRNA methyltransferases in Drosophila that modulate small RNA silencing and lifespan by modifying specific tRNAs.

Nucleic Acids Research · Jan 9, 2020Peer-reviewedMolecular Biology