Myunghwan Choi

A modular cranial window enabling maintainable widefield optical access in non-human primates

This paper introduces a modular cranial window for long-term optical imaging in awake macaques, enabling maintainable access and reducing tissue degradation.

Comparative connectomics reveals stage-specific gap junction rewiring that reshapes avoidance behavior

This study shows that dauer-specific gap junction rewiring in C. elegans shortens avoidance duration while preserving initiation, revealing how circuit reorganization balances flexibility and stability under stress.

Optical segmentation-based compressed readout of neuronal voltage dynamics

This paper introduces a novel optical segmentation method for compressed readout of neuronal voltage dynamics, achieving high-speed recording of subcellular activity with improved data efficiency.

Gustatory-neuron-supplied R-spondin-2 is required for taste bud replenishment

This study shows that Rspo2 from gustatory neurons is essential for taste bud maintenance through genetic experiments in mice.

CoVET: Cryo-Electron Tomography guided by optical electrophysiology

The paper develops CoVET, a technique correlating electrophysiological properties with cryo-ET to analyze neuronal molecular structures and translational landscapes.

Brain Representations of Affective Valence and Intensity in Sustained Pleasure and Pain

This study uses fMRI to identify brain regions and networks associated with affective valence and intensity during sustained pleasure and pain, showing distinct neural coding for each.

Whole-brain mapping of effective connectivity by fMRI with cortex-wide patterned optogenetics

This study uses fMRI with optogenetic stimulation to map whole-brain effective connectivity in mice, showing agreement with anatomical data but sensitivity to anesthetics.

All-optical observation on activity-dependent nanoscale dynamics of myelinated axons

This study uses an all-optical method to observe activity-dependent nanoscale swelling in myelinated axons in living brain slices.

Statistically unbiased prediction enables accurate denoising of voltage imaging data

SUPPORT is a self-supervised method that denoises voltage imaging data by leveraging spatiotemporal dependencies, preserving dynamics without requiring action potential information.

Comprehensive functional screening of taste sensation in vivo

The paper develops a microfluidics-based platform to screen taste cell function in vivo, revealing 70% single-tuned and 30% dual-tuned cells, including a novel dual-tuned population encoding positive valence.