Guillaume de Lartigue

This study identifies intestinal serotonergic vagal signaling as a key mediator of microbiota-induced hypertension, showing that reduced 5-HT and 5HT3aR signaling contributes to hypertension and can be reversed to alleviate it.

This study shows lithium affects behavior and physiology through the gut-brain axis by activating gut enterochromaffin cells, challenging the belief that lithium acts directly on the brain.

This study shows that Rspo2 from gustatory neurons is essential for taste bud maintenance through genetic experiments in mice.

The paper identifies ventral hippocampus neurons that encode meal-related memories and shows their role in spatial memory and feeding behavior.

This study identifies vagal afferents expressing the oxytocin receptor that mediate mechanosensation of the heart and gut, leading to hypometabolism and vigilance in mice.

The paper identifies lateralized vagal sensory neurons with distinct roles in satiety and food preference, revealing asymmetrical gut-brain circuits that control feeding behavior.

The paper identifies separate vagal reward circuits for fat and sugar that drive overeating when both are activated, even when calorie intake is controlled.

The paper shows that central and peripheral GLP-1 systems independently suppress eating, and PPGNTS neuron activation addsitively enhances this effect with GLP-1 agonists.

This study shows that ghrelin signaling through vagal afferent neurons affects feeding, metabolism, and memory by targeting GHSR on these neurons.