Thomas Möritz

Suspension culture drives metabolic rewiring in human pluripotent stem cells

This study compares 2D and 3D suspension cultures of human pluripotent stem cells, finding metabolic rewiring in 3D cultures with increased glycolysis and altered TCA cycle carbon partitioning.

Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of interorganellar lipid cycling

This paper identifies SLC25A34 as a key regulator of interorganellar lipid cycling, integrating circadian rhythms, diet, and temperature to control thermogenic metabolism.

TCA cycle rewiring underpins implantation and histone acetylation programming

This study reveals that TCA cycle rewiring at implantation supports histone acetylation programming and pluripotency transitions in mouse embryos.

Lysine Potentiates Insulin Secretion via AASS-Dependent Catabolism and Regulation of GABA Content and Signaling

This study shows lysine enhances insulin secretion through AASS-dependent catabolism, which regulates GABA content and mitochondrial function in beta cells.

Multiomics and digital monitoring during lifestyle changes reveal independent dimensions of human biology and health

The paper integrates multiomics and digital health data from 96 individuals over 16 months to identify independent molecular factors linked to health outcomes and lifestyle changes.