Author

Bryce J. Wick

University of MinnesotaORCID 0000-0002-2844-0898Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Approach:genetic perturbation / CRISPR· 3 Organism:human· 3 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Beau R. WebberiD· 4 shared Branden S. MoriarityiD· 4 shared Joseph G. SkeateiD· 3 shared Mitchell G. KluesneriD· 3 shared Nicholas J. SlipekiD· 3 shared Bibekananda KariD· 2 shared Erin M. Stelljes· 2 shared Ethan M. Niemeyer· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBioengineering

Beau R. WebberORCID

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Author profile →

4 papers

Recent·Most cited

A Singular Base Editing Platform for Polyfunctional Multiplex Engineering of Immune Cells

Joseph G. Skeate, Nicholas J. Slipek, Walker S. Lahr, Shambojit Roy, Bryce J. Wick, Bibekananda Kar, Jae-Woong Chang, Erin M. Stelljes, Alexandria K. Gilkey, Prateek P. Thenge, Miechaleen D. Diers, Joshua B. Krueger, Ethan M. Niemeyer, Cara-lin Lonetree, Mitchell G. Kluesner, , Beau R. Webber

This paper develops a base editing platform to efficiently and safely engineer CAR T cells with multiple gene knockouts and insertions.

Molecular Therapy · Jul 18, 2026Peer-reviewedBioengineering

Efficient multiplex non-viral engineering and expansion of polyclonal γδ CAR-T cells for immunotherapy

Jacob E. Bridge, Matthew J. Johnson, Bibekananda Kar, Jihyun Kim, Sophia J. Wenthe, Joshua B. Krueger, Bryce J. Wick, Mitchell G. Kluesner, Andrew T. Crane, Jason Bell, Lage von Dissen, Erin M. Stelljes, Joseph G. Skeate, Branden S. Moriarity, Beau R. Webber

This paper develops a scalable, non-viral method to engineer and expand polyclonal γδ CAR-T cells, showing their functional efficacy and subset-specific responses in vivo.

Molecular Therapy · Mar 11, 2026Peer-reviewedImmunology

Installation of Dominant-Negative Mutations in FAS and TGFβR2 via Base Editing in Primary T Cells

Bryce J. Wick, Mitchell G. Kluesner, Nicholas J. Slipek, Joseph G. Skeate, Ethan M. Niemeyer, Beau R. Webber, Branden S. Moriarity

This paper uses base editing to introduce dominant-negative mutations in FAS and TGFβR2 in primary T cells, enhancing their anti-tumor efficacy and persistence in solid tumor models.

Molecular Therapy Oncology · Sep 24, 2025Peer-reviewedImmunology

Engineering Memory T Cells as a platform for Long-Term Enzyme Replacement Therapy in Lysosomal Storage Disorders

Evan W. Kleinboehl, Kanut Laoharawee, Jacob D. Jensen, Joseph J. Peterson, Nicholas J. Slipek, Bryce J. Wick, Matthew J. Johnson, Beau R. Webber, Branden S. Moriarity

This study demonstrates that genetically engineered memory T cells can deliver enzyme replacement therapy for mucopolysaccharidosis type I, reducing GAG levels in multiple tissues for up to 22 weeks.

Molecular Therapy · Oct 4, 2024Peer-reviewedBioengineering