The paper investigates how post-transcriptional modifications on tRNA fragments in HDL affect atherosclerosis by altering immune signaling and macrophage activation.

Atherosclerosis · Nov 20, 2025Peer-reviewedCell Biology

Molecular architecture of human atherosclerosis revealed through integrative human genetics

Bassim R. El-Sabawi, Michael J. Betti, P. Charles Lin, Xiaoning Huang, Namju Kim, Mohammad Yaser Anwar, Andrew Perry, B. Lakshitha A. Perera, Priya Gajjar, Laura Anne Colangelo, Kaushik V Amancherla, Quanhu Sheng, Shilin Zhao, Lindsey K. Stolze, Eric H. Farber‐Eger, , Ravi V. Shah

The paper integrates proteomics and transcriptomics with genetic analyses to identify molecular mechanisms and targets of coronary artery disease.

medRxiv · Mar 6, 2025 · PreprintGenetic & Genomic Medicine

Physico-chemical principles of HDL-small RNA binding interactions.

Danielle L. Michell, Ryan M. Allen, Ashley B. Cavnar, Danielle M. Contreras, Minzhi Yu, Elizabeth M. Semler, Clark Massick, Chase A. Raby, Mark Castleberry, Marisol Adelina Ramirez, Wanying Zhu, Linda Zhang, Anca Ifrim, J. Jeffrey Carr, James Greg Terry, , Kasey C. Vickers

The paper investigates how HDL binds to single-stranded small RNAs through interactions with apoA-I, revealing mechanisms that may enable extracellular RNA communication.

Journal of Biological Chemistry · Apr 18, 2022Peer-reviewedMolecular Biology