Danielle L. Michell

Post-transcriptional modifications on tRNA fragments confer functional changes to high-density lipoproteins in atherosclerosis

The paper investigates how post-transcriptional modifications on tRNA fragments in HDL affect atherosclerosis by altering immune signaling and macrophage activation.

Lipid-siRNA conjugate accesses a perivascular transport mechanism and achieves widespread and durable knockdown in the central nervous system

This study develops a lipid-siRNA conjugate that uses perivascular transport to achieve long-lasting gene knockdown in the CNS without toxicity.

5-Fluorouracil Treatment Represses Pseudouridine-Containing Small RNA Export into Extracellular Vesicles

This study shows that 5-FU treatment alters the export and base modifications of small RNAs in extracellular vesicles from colorectal cancer cells.

Physico-chemical principles of HDL-small RNA binding interactions.

The paper investigates how HDL binds to single-stranded small RNAs through interactions with apoA-I, revealing mechanisms that may enable extracellular RNA communication.

Bioinformatic analysis of endogenous and exogenous small RNAs on lipoproteins

The paper introduces TIGER, a pipeline for analyzing extracellular small RNAs, demonstrating its ability to identify sRNAs on lipoproteins and in biofluids with high accuracy.