The paper investigates how post-transcriptional modifications on tRNA fragments in HDL affect atherosclerosis by altering immune signaling and macrophage activation.

Atherosclerosis · Nov 20, 2025Peer-reviewedCell Biology

Lipid-siRNA conjugate accesses a perivascular transport mechanism and achieves widespread and durable knockdown in the central nervous system

Alexander G. Sorets, Katrina R Schwensen, Nora Francini, Andrew Kjar, Adam M Abdulrahman, Alena Shostak, Ketaki A. Katdare, Kathleen M. Schoch, Rebecca P. Cowell, Joshua C. Park, Alexander P Ligocki, William T Ford, Lissa Ventura‐Antunes, Ella N. Hoogenboezem, Alex Prusky, , Ethan S. Lippmann

This study develops a lipid-siRNA conjugate that uses perivascular transport to achieve long-lasting gene knockdown in the CNS without toxicity.

Nucleic Acids Research · Jun 20, 2025Peer-reviewedBioengineering

Physico-chemical principles of HDL-small RNA binding interactions.

Danielle L. Michell, Ryan M. Allen, Ashley B. Cavnar, Danielle M. Contreras, Minzhi Yu, Elizabeth M. Semler, Clark Massick, Chase A. Raby, Mark Castleberry, Marisol Adelina Ramirez, Wanying Zhu, Linda Zhang, Anca Ifrim, J. Jeffrey Carr, James Greg Terry, , Kasey C. Vickers

The paper investigates how HDL binds to single-stranded small RNAs through interactions with apoA-I, revealing mechanisms that may enable extracellular RNA communication.

Journal of Biological Chemistry · Apr 18, 2022Peer-reviewedMolecular Biology