Author

Elizabeth M. Semler

Vanderbilt UniversityORCID 0000-0002-0271-2728Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

Clark MassickiD· 3 shared Danielle L. MichelliD· 3 shared Kasey C. VickersiD· 3 shared J. Jeffrey CarriD· 2 shared MacRae F. LintoniD· 2 shared Marisol Adelina RamireziD· 2 shared Mark CastleberryiD· 2 shared Quanhu ShengiD· 2 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersMolecular Biology

Clark MassickORCID

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Author profile →

3 papers

Recent·Most cited

Post-transcriptional modifications on tRNA fragments confer functional changes to high-density lipoproteins in atherosclerosis

Elizabeth M. Semler, Danielle L. Michell, Philip J. Kingsley, Marisol Adelina Ramirez, Clark Massick, Mark Castleberry, Amanda C. Doran, J. Jeffrey Carr, Lawrence J. Marnett, Quanhu Sheng, MacRae F. Linton, Kasey C. Vickers

The paper investigates how post-transcriptional modifications on tRNA fragments in HDL affect atherosclerosis by altering immune signaling and macrophage activation.

Atherosclerosis · Nov 20, 2025Peer-reviewedCell Biology

5-Fluorouracil Treatment Represses Pseudouridine-Containing Small RNA Export into Extracellular Vesicles

Sherman Qu, Hannah Nelson, Xiao Liu, Elizabeth M. Semler, Danielle L. Michell, Clark Massick, Jeffrey L. Franklin, John J. Karijolich, Alissa M. Weaver, Robert J. Coffey, Qi Liu, Kasey C. Vickers, James G. Patton

This study shows that 5-FU treatment alters the export and base modifications of small RNAs in extracellular vesicles from colorectal cancer cells.

bioRxiv · Jan 15, 2024 · PreprintMolecular Biology

Physico-chemical principles of HDL-small RNA binding interactions.

Danielle L. Michell, Ryan M. Allen, Ashley B. Cavnar, Danielle M. Contreras, Minzhi Yu, Elizabeth M. Semler, Clark Massick, Chase A. Raby, Mark Castleberry, Marisol Adelina Ramirez, Wanying Zhu, Linda Zhang, Anca Ifrim, J. Jeffrey Carr, James Greg Terry, , Kasey C. Vickers

The paper investigates how HDL binds to single-stranded small RNAs through interactions with apoA-I, revealing mechanisms that may enable extracellular RNA communication.

Journal of Biological Chemistry · Apr 18, 2022Peer-reviewedMolecular Biology