Xiyue Leng

This paper explores sequence constraints for de novo 310-helical bundles by mutating key residues in a designed peptide and assessing stability and functionality.

The paper designs de novo all-α-helical proteins using computational methods and validates their stability and structure.

This study shows that cargo-sensitive TPR switch in kinesin-1 controls its conformational dynamics by dislocating the TPR shoulder, promoting motor domain activation and microtubule binding.

This paper designs 3-helix bundle peptides and proteins with controlled topology and stability using computational methods and experimental validation.