Jonathan Clayden

This paper explores sequence constraints for de novo 310-helical bundles by mutating key residues in a designed peptide and assessing stability and functionality.

The paper designs de novo all-α-helical proteins using computational methods and validates their stability and structure.

This paper designs 3-helix bundle peptides and proteins with controlled topology and stability using computational methods and experimental validation.

This paper designs and characterizes synthetic protein assemblies composed of 310 helices, demonstrating their ability to form stable structures despite their rarity in natural proteins.