This study uses spatial transcriptomics to analyze MDA5+ dermatomyositis muscles, revealing distinct transcriptomic profiles, immune cell infiltration, and vascular inflammation.

bioRxiv · Jan 5, 2026 · PreprintImmunology

DNA G-quadruplex Profiling Reveals Functional and Mechanistic Role of G-quadruplexes in Skeletal Muscle Stem Cells

Xiaona Chen, Feng Yang, Suyang Zhang, Xiaofan Guo, Jieyu Zhao, Yulong Qiao, Liangqiang He, Yang Li, Qin Zhou, Michael Tim‐Yun Ong, Chun Kit Kwok, Hao Sun, Huating Wang

This study maps G-quadruplexes in skeletal muscle stem cells and shows their role in promoting activation and regeneration through chromatin looping and transcription factor binding.

Genome biology · Sep 5, 2025Peer-reviewedMolecular Biology

Multiomics mapping and characterization of cellular senescence in aging human skeletal muscle uncovers a novel senotherapeutic for sarcopenia

Yang Li, Chuhan Li, Qin Zhou, Xingyuan Liu, Yulong Qiao, Ting Xie, Hao Sun, Michael Tim‐Yun Ong, Huating Wang

This study uses single-nucleus multiomics to characterize senescence in human skeletal muscle, identifies SASP factors, and proposes Maraviroc as a senotherapeutic for sarcopenia.

Nature Communications · Jul 5, 2025Peer-reviewedCell Biology