Luke V. Rasmussen

Pathogen-specific host responses define distinct pneumonia endotypes in the human lung

This study identifies distinct pneumonia endotypes based on pathogen-specific host responses in the lung, linking them to clinical outcomes and suggesting personalized treatment strategies.

Novel enzyme-based reduced representation method for DNA methylation profiling with low inputs

This paper introduces RREM-seq, an enzyme-based reduced representation DNA methylation sequencing method that enables high-resolution profiling of low-input samples, including clinical specimens.

A distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia

The paper examines alveolar T cell responses in SARS-CoV-2 pneumonia patients, finding that early interferon signaling and targeting of structural proteins correlate with better clinical outcomes.

Developing a standardized but extendable framework to increase the findability of infectious disease datasets

The paper develops a metadata schema based on Schema.org to improve the findability of infectious disease datasets and computational tools across repositories.

Genomic Considerations for FHIR; eMERGE Implementation Lessons

This paper describes the implementation of HL7 FHIR standards for representing clinical genomics results in the eMERGE Networks, improving interoperability for genetic data management.

Multi-ancestry Genome- and Phenome-wide Association Studies of Diverticular Disease in Electronic Health Records with Natural Language Processing enriched phenotype algorithm

This study uses NLP to identify diverticular disease from EHRs and performs GWAS and PheWAS across multiple ancestries to find genetic risk variants and clinical associations.