Edmund R Hollis II

Conditioning electrical stimulation enhances functional rewiring in a mouse model of nerve transfer to treat chronic spinal cord injury

A Kinematic Deviation Index (KDI) for Evaluation of Forelimb Function in Rodents

The paper introduces a kinematic deviation index (KDI) to assess forelimb function in rodents, demonstrating its ability to detect movement differences and response to interventions.

Neuropathic pain in a chronic CNS injury model is mediated by CST-targeted spinal interneurons

This study identifies CST-targeted spinal interneurons as a key circuit in chronic neuropathic pain following CNS injury in mice.

The composition of motor recovery revealed by syllable-level behavioral analysis after spinal cord injury

This study uses motion sequencing to analyze behavioral syllables after spinal cord injury, revealing recovery patterns shaped by injury severity and individual differences.

Nicotinic signaling is required for motor learning but not rehabilitation after spinal cord injury

This study shows that nicotinic signaling is necessary for motor learning but not for rehabilitation of previously learned movements after spinal cord injury.

Basal forebrain cholinergic neurons selectively drive coordinated motor learning in mice

This study shows that cholinergic neurons in the basal forebrain are essential for acquiring coordinated motor skills in mice, but not for executing learned tasks.

Task-specific modulation of corticospinal neuron activity during skilled motor learning

This study investigates how corticospinal neuron activity changes during skilled versus unskilled motor learning and shows that patterned network activity is essential for skilled movement execution.

Analysis of the Immune Response to Sciatic Nerve Injury Identifies Efferocytosis as a Key Mechanism of Nerve Debridement

This study identifies efferocytosis as a key mechanism for nerve debridement following sciatic nerve injury through single-cell RNA-sequencing and genetic analysis.

Temporal regulation of motor behavior on a modified forelimb dexterity test in mice

The paper introduces a modified single pellet reach task to assess forelimb dexterity in mice and shows that cortical inactivation affects different motor components at distinct times.