Alpha-BET: Functional labeling of envelope glycoproteins with single domain antibodies for in-virus single molecule imaging
David J. Williamson, Cecilia Zaza, Irene Carlón-Andrés, Alessia Gentili, Janet M. Daly, Harry Holmes, Joseph W. Thrush, Tobias Starling, Stuart J. D. Neil, Raymond J. Owens, Michael H. Malim, Christopher J. Tynan, Sabrina Simoncelli, Sergi Padilla‐Parra
Alpha-BET uses AlphaFold to identify optimal sites for labeling viral glycoproteins with nanobodies, enabling high-resolution imaging of viral structures without disrupting their function.
bioRxiv · Apr 11, 2025 · PreprintBiophysics