Early HIV-1 maturation drives Env clustering and fusion competence
Irene Carlón-Andrés, Victoria Garcia-Giner, David J. Williamson, Ravi Teja Ravi, Audrey Le Bas, Philip N. Ward, Tobias Starling, Lina El Hajji, Arnaud Gautier, Sabrina Simoncelli, Michael Grange, Maud Dumoux, Sergi Padilla‐Parra
This study shows that early HIV-1 maturation steps, specifically partial Gag cleavage, promote Env clustering and fusion competence by reorganizing the membrane-proximal lattice.
bioRxiv · Dec 11, 2025 · PreprintMicrobiology