Author

Chloe Wick

Stanford UniversityORCID 0009-0002-0463-8178Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:plant (other)· 2 Assay:bulk RNA-seq· 1 Organism:chicken / avian· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Chun‐Ting LiuiD· 2 shared Conor James McCluneiD· 2 shared Elizabeth S. SattelyiD· 2 shared Polly Morrell FordyceiD· 2 shared Alison J. BarkhymeriD· 1 shared Anish SomaniiD· 1 shared Autumn E. SandersiD· 1 shared Bernd Markus LangeiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

Chun‐Ting LiuORCID

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3 papers

Recent·Most cited

FoTO1 orchestrates Taxol biosynthesis through catalytic and non-catalytic mechanisms

Chloe Wick, Anish Somani, Chun‐Ting Liu, Sumudu S Karunadasa, Shou‐Ling Xu, Polly Morrell Fordyce, Conor James McClune, Elizabeth S. Sattely

This paper identifies FoTO1 as a dual-function enzyme that enhances Taxol biosynthesis through catalytic conversion and non-catalytic organization of P450s in plants.

bioRxiv · Mar 24, 2026 · PreprintBiochemistry

Mammalian ZAP and KHNYN can independently restrict CpG-enriched avian viruses

Jordan T. Becker, Clayton K. Mickelson, Lauren M. Pross, Autumn E. Sanders, Esther R. Vogt, Frances K. Shepherd, Chloe Wick, Alison J. Barkhymer, Stephanie L. Aron, Elizabeth J. Fay, Reuben S. Harris, Ryan Andrew Langlois

The paper shows mammalian ZAP and KHNYN can restrict CpG-enriched avian viruses, with human ZAP or KHNYN independently limiting CpG-enriched IAV in chicken and human cells.

PLoS Biology · Oct 28, 2025Peer-reviewedMicrobiology

Multiplexed perturbation of yew reveals cryptic proteins that enable a total biosynthesis of baccatin III and Taxol precursors

Conor James McClune, Chun‐Ting Liu, Chloe Wick, Ricardo De La Peña, Bernd Markus Lange, Polly Morrell Fordyce, Elizabeth S. Sattely

A multiplexed perturbation and single-nucleus RNA-seq screen of Taxus needles found eight new Taxol pathway genes, including FoTO1, enabling baccatin III and a late Taxol precursor in N. benthamiana.

Nature · Jun 11, 2025Peer-reviewedBiochemistry✦ In-depth digest