This study sequenced 25 new Rickettsia typhi genomes, expanding the dataset to 29 complete genomes, revealing minimal genetic diversity and a clonal population structure.

PLoS neglected tropical diseases · Dec 29, 2025Peer-reviewedMicrobiology

The mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional response.

Lei Zhu, Rob W. van der Pluijm, Michal Kucharski, Sourav Nayak, Jaishree Tripathi, François Henry Nosten, Abul Faiz, Chanaki Amaratunga, Dysoley Lek, Elizabeth A. Ashley, Frank M. Smithuis, Aung Pyae Phyo, Khin Lin, Mallika Imwong, Mayfong Mayxay, , Zbynek Bozdech

The paper identifies a transcriptional profile in artemisinin-resistant Plasmodium falciparum that originates from initial drug responses and involves proteotoxic stress and REDOX metabolism.

bioRxiv · May 17, 2021 · PreprintSystems Biology

Oxford Nanopore MinION sequencing enables rapid whole-genome assembly of Rickettsia typhi in a resource-limited setting

Ivo Elliott, Elizabeth M. Batty, Damien Keng Yen Ming, Matthew T. Robinson, Pruksa Nawtaisong, Mariateresa de Cesare, Paul N. Newton, Rory J. Bowden

This study evaluates the accuracy of Oxford Nanopore MinION sequencing for whole-genome assembly of Rickettsia typhi in resource-limited settings, finding it insufficient for phylogenetic analysis but useful with error correction.

American Journal of Tropical Medicine and Hygiene · Dec 10, 2019Peer-reviewedGenomics