Dysoley Lek

Genetic relatedness of Cambodian Plasmodium falciparum isolates is driven by geography and occupation

The paper assesses genetic relatedness of Plasmodium falciparum isolates in Cambodia, finding high IBD sharing linked to geography and occupation.

Rapid detection of G6PD deficiency SNPs using a novel amplicon-based MinION Sequencing Assay

This paper develops a cost-effective MinION sequencing assay to detect G6PD deficiency SNPs in malaria-endemic regions, showing high reliability and concordance with Sanger sequencing.

Using a P. falciparum genetic cross to dissect the relative contributions of pfcrt and plasmepsin II/III to piperaquine response-related traits

This study uses a genetic cross of Plasmodium falciparum isolates to analyze the roles of pfcrt and pm2/3 in piperaquine resistance and fitness traits.

Optimizing bulk segregant analysis of drug resistance using Plasmodium falciparum genetic crosses conducted in humanized mice

This study optimizes bulk segregant analysis for identifying drug resistance loci in Plasmodium falciparum using genetic crosses in humanized mice, confirming the kelch13 locus and demonstrating the utility of cryopreserved pools.

The mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional response.

The paper identifies a transcriptional profile in artemisinin-resistant Plasmodium falciparum that originates from initial drug responses and involves proteotoxic stress and REDOX metabolism.