Author

Ye Tian

Chinese Academy of SciencesORCID 0000-0002-7675-9270Unclaimed ORCID profile · follow to get notified of new preprints

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Ye Tian6 papers · Department of Otorhinolaryngology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, Guangdong, China;

Biology Disciplines

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Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Changchang XiniD· 1 shared Christopher J. LengneriD· 1 shared Devon Bankler-Jukes· 1 shared JH Rhoades· 1 shared Jianhang Yin· 1 shared Jiasheng LiiD· 1 shared Jiazhi HuiD· 1 shared Jinchun WuiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperGenomics

Changchang XinORCID

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2 papers

Recent·Most cited

APC loss promotes intestinal transformation through induction of bistable stem cell states

N Li, RL Myers, Qin Zhu, Ye Tian, Kayla Durning, X Wang, NA Leu, JH Rhoades, Devon Bankler-Jukes, Keara Monaghan, Stephanie Adams‐Tzivelekidis, Oz Pomp, Oscar Pellón-Cárdenas, Mario Andres Blanco, Michael Paul Verzi, , Christopher J. Lengner

This study identifies that APC loss in colorectal cancer drives a β-CATENIN-independent fetal intestinal transcriptional program through YAP activation, leading to bistable stem cell states and enhanced tumorigenesis.

bioRxiv · Mar 6, 2025 · PreprintCancer Biology

Transfer of mitochondrial DNA into the nuclear genome during gene editing

Jinchun Wu, Yang Liu, Liqiong Ou, Tingting Gan, Zhengrong Zhangding, Shaopeng Yuan, Mengzhu Liu, Xinyi Liu, Jiasheng Li, Jianhang Yin, Changchang Xin, Ye Tian, Jiazhi Hu

This study shows that genome editing can transfer mitochondrial DNA into the nuclear genome, and provides a solution using TREX1 or TREX2 exonucleases.

bioRxiv · Jul 19, 2023 · PreprintGenomics