Luke A. Selth

Profiling of epithelial functional states and fibroblast phenotypes in hormone therapy-naive localised prostate cancer

This study uses single-cell RNA-sequencing and spatial transcriptomics to analyze epithelial and fibroblast states in hormone therapy-naive prostate cancer, identifying novel phenotypes and molecular perturbations.

The landscape of alternative polyadenylation during EMT and its regulation by the RNA-binding protein Quaking

The paper maps alternative polyadenylation changes during EMT in human mammary epithelial cells and identifies QKI's role in regulating APA and gene expression.

Estrogen receptor alpha controls gene expression via translational offsetting

This study shows estrogen receptor alpha (ER) regulates gene expression by coordinating transcription with translational offsetting, maintaining protein levels despite changes in mRNA abundance.