Author

Karen Sachs

Massachusetts Institute of Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:scRNA-seq· 2 Assay:ATAC-seq· 1 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1

Frequent Co-Authors

Aaron P. Frank· 1 shared Alan Gi-Lun ChengiD· 1 shared Alex Lenail· 1 shared Alina P. Bogachuk· 1 shared Alyssa N. CoyneiD· 1 shared Andrea D. MatlockiD· 1 shared Andrew Tai-Ann ChengiD· 1 shared Aude ChiotiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperNeuroscience

Aaron P. Frank

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2 papers

Recent·Most cited

Single-cell, spatial, and fate-mapping analyses uncover niche dependent diversity of cochlear myeloid cells.

Aude Chiot, Max J. Felgner, Dillon Brownell, Katherine H. Rott, Alina P. Bogachuk, Dennis-Dominik Rosmus, Takahiro Masuda, Audrey Ching, Patrick J. Atkinson, Marco Prinz, Karen Sachs, Alan Gi-Lun Cheng, Peter Wieghofer, Bahareh Ajami

This study identifies five myeloid cell types in the mouse cochlea using single-cell transcriptomics, fate mapping, and parabiosis, revealing their spatial distribution, ontogeny, and functional diversity.

bioRxiv · Oct 30, 2024 · PreprintImmunology

An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients

Loren Ornelas, Emilda Gomez, Lindsay Panther, Aaron P. Frank, Susan Lei, Berhan Mandefro, Maria G. Bañuelos, Brandon Shelley, Julia Kaye, Leandro de Araújo Lima, Stacia K. Wyman, Ryan G. Lim, Jie Wu, Jennifer T. Stocksdale, Malcolm Casale, , Leslie Michels Thompson

The paper performs an integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients to identify dysregulated pathways and validate them in vivo and in postmortem data.

bioRxiv · Nov 1, 2020 · PreprintNeuroscience