Author

Elien Hilgert

Ghent UniversityORCID 0000-0002-4715-6972Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Ellen SandersiD· 2 shared Kaat DurinckiD· 2 shared Alexander M.M. EggermontiD· 1 shared Anna A. SablinaiD· 1 shared Arne ClaeysiD· 1 shared Bengt HallbergiD· 1 shared C. Nunes· 1 shared Elisa de StanchinaiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Ellen SandersORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

RUVBL1 and RUVBL2 are druggable MYCN regulators in neuroblastoma.

Joachim Tetteh Siaw, Arne Claeys, Wei‐Yun Lai, Marcus Borenäs, Elien Hilgert, Sarah-Lee Bekaert, Ellen Sanders, İrem Kaya, Jo Van Dorpe, Frank Speleman, Kaat Durinck, Bengt Hallberg, Ruth Helen Palmer, Jimmy Van den Eynden

This study identifies RUVBL1 and RUVBL2 as druggable regulators of MYCN in neuroblastoma, showing their inhibition reduces MYC signaling and induces cell cycle arrest and apoptosis.

iScience · Mar 5, 2026Peer-reviewedCancer Biology

5UTR translational inhibition of neuroblastoma dependency factors using the CR-1-31-B rocaglate

C. Nunes, S.-L. Bekaert, S. Parsa, Iris H. Nelen, F. Martens, Elisa de Stanchina, Ellen Sanders, Elien Hilgert, Sara T’Sas, P. Zhao, Fanny De Vloed, Alexander M.M. Eggermont, Steven Goossens, Anna A. Sablina, Lisa Depestel, , Kaat Durinck

This study evaluates CR-1-31-B's effects on neuroblastoma, showing reduced tumor growth and revealing translational inhibition of key dependencies and synergistic effects with CHK1 inhibition.

bioRxiv · Aug 29, 2024 · PreprintCancer Biology