This study longitudinally tracks antigen-specific T cells in human upper airway tissues and blood, finding sustained memory T cell populations over 18 months.

bioRxiv · Sep 18, 2026 · PreprintImmunology

Local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans

Hannah D. Stacey, Lucas Garin-Ortega, Paul G. Lopez, Parham Ramezani-Rad, Sydney I. Ramirez, Farhoud Faraji, Disha Bhavsar, Gina Levi, Florian Krammer, Shane Crotty

This study shows that intranasal influenza vaccination generates durable local B cell memory in the upper airway, while intramuscular vaccination does not.

bioRxiv · Jul 14, 2025 · PreprintImmunology

Profiling Transcription Initiation in Peripheral Leukocytes Reveals Severity-Associated Cis-Regulatory Elements in Critical COVID-19

Michael T. Y. Lam, Sascha H. C. Duttke, Mazen Faris Odish, Hiep Dinh Le, Emily A. Hansen, Celina T. Nguyen, Samantha Trescott, Roy Y. Kim, Shaunak Deota, Max W. Chang, Arjun Patel, Mark Hepokoski, Mona Alotaibi, Mark L. Rolfsen, Katherine Perofsky, , Nicole G. Coufal

The paper profiles the active cistrome in peripheral leukocytes of critically ill COVID-19 patients to identify severity-associated cis-regulatory elements and their regulatory programs.

Cell Reports Medicine · Jan 25, 2023Peer-reviewedGenomics

AI-guided discovery of the invariant host response to viral pandemics

Debashis Sahoo, Gajanan Dattatray Katkar, Soni Khandelwal, Mahdi Behroozikhah, Amanraj Claire, Vanessa Castillo, Courtney Tindle, MacKenzie R. Fuller, Sahar Taheri, Thomas F. Rogers, Nathan Beutler, Sydney I. Ramirez, Stephen A. Rawlings, Victor Gert Pretorius, Davey Mitchell Smith, , Pradipta Ghosh

The paper identifies a conserved 166-gene host immune signature across viral pandemics, with a 20-gene subset predicting disease severity and guiding therapeutic strategies.

EBioMedicine · Jun 1, 2021Peer-reviewedBioinformatics