Author
Institució Catalana de Recerca i Estudis AvançatsORCID 0000-0002-4750-7971Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Konstantinos Stamatiou, Lorena Ligammari, Malki Bothota, Antonia Tsavou, Ezgi Gokhan, Ylenia Cicirò, Mariano F. Zacarías Fluck, Laura Soucek, Arturo Sala, Paola Vagnarelli
The paper identifies a CDCA2-MYC positive feedback loop that promotes cancer cell survival in multiple cancer types.
Open Biology · Mar 11, 2026Peer-reviewedCell Biology
Motoyuki Tsuda, Dove J. Keith, Colin J. Daniel, Carl Pelz, Katie E. Blise, Tugba Y. Ozmen, Furkan Ozmen, Kevin Hawthone, Jennifer R. Eng, Xi Li, Xiaoyan Wang, Hayley Zimny, Shamilene Sivagnanam, Konjit Betre, Nell C. Kirchberger, , Rosalie C. Sears
The paper identifies resistance mechanisms to KRAS-MEK pathway targeting in PDAC by analyzing clinical trial data and multi-omics profiles, showing that KRAS/MYC co-gain correlates with resistance and that co-targeting these genes is synergistic.
bioRxiv · Dec 15, 2025 · PreprintCancer Biology
Paola Pellanda, Mattia Dalsass, M. Filipuzzi, Alessia Loffreda, Alessandro Verrecchia, Virginia Castillo Cano, Hugo Thabussot, Mirko Doni, Marco J. Morelli, Laura Soucek, Theresia R. Kress, Davide Mazza, Marina Mapelli, Marie-Ève Beaulieu, Bruno B. Amati, Arianna Sabò
This study shows that MYC uses both non-specific and sequence-specific DNA binding to regulate transcription, with sequence-specific binding contributing to transcriptional activation.
The EMBO Journal · Apr 1, 2021Peer-reviewedMolecular Biology