This study shows vimentin intermediate filaments reorganize to mobilize ER-endosome contact sites, promoting autophagosome biogenesis during starvation.

Journal of Cell Science · Jul 15, 2026Peer-reviewedCell Biology

Keratin intermediate filaments mechanically position melanin pigments for genome photoprotection

Silvia Benito-Martínez, Laura Salavessa, Anne‐Sophie Macé, Myckaëla Rouabah, Nathan Lardier, Vincent Fraisier, Julia Sirés-Campos, Riddhi Atul Jani, Maryse Romao, Vanessa Roca, Charlène Gayrard, Marion Plessis, Ilse Hurbain, Cécile Nait‐Meddour, Sandrine Etienne‐Manneville, , Cédric Delevoye

The paper shows keratin 5/14 intermediate filaments position melanin pigments near the nucleus to protect DNA from UV damage, using human keratinocyte models and imaging.

Nature Cell Biology · Dec 15, 2025Peer-reviewedCell Biology

Influenza A virus-induced production of PI4P at the endoplasmic reticulum involves ATG16L1 and promotes the egress of viral ribonucleoproteins

Carla Alemany, Juliane Da Graça, Quentin Giai Gianetto, Maud Dupont, Sylvain Paisant, Thibaut Douché, Catherine Isel, Cédric Delevoye, Lydia Danglot, Mariette Matondo, Étienne Morel, Jean‐Baptiste Brault, Nadia Naffakh

This study identifies ATG16L1's role in IAV-induced PI4P production at the ER, facilitating vRNP egress by coordinating RAB11A and PI4P-enriched membranes.

PLoS Biology · Jul 16, 2025Peer-reviewedMicrobiology

On the Role of VP3-PI3P Interaction in Birnavirus Endosomal Membrane Targeting

Flavia Zanetti, Ignacio Fernandez, Eduard Baquero, Pablo Guardado‐Calvo, Andres Ferrino-Iriarte, Sarah Dubois, Étienne Morel, Victoria Alfonso, Milton Osmar Aguilera, María E Celayes, Luis Mariano Polo, Laila Suhaiman, Vanesa Viviana Galassi, María V. Chiarpotti, Carolina Allende-Ballestero, , Laura Ruth Delgui

This paper investigates how VP3 protein of birnaviruses targets endosomal membranes via PI3P binding, revealing a two-stage mechanism critical for viral replication.

bioRxiv · Feb 20, 2024Microbiology