Enzo Mameli

The paper uses a pro-apoptotic CRISPR screening strategy in mosquito cells to identify Lachesin as a critical CHIKV entry factor.

This study identifies Lachesin as a mosquito receptor for multiple arthritogenic alphaviruses using CRISPR screening in Aedes albopictus cells.

The paper develops a genome-wide CRISPR-Cas9 knockout screening platform for Ixodes scapularis ticks and identifies genes associated with cellular fitness and drug resistance.

The paper develops and characterizes gene drive docking lines in Anopheles gambiae using RMCE and HACK techniques, identifies challenges for robust gene drive development.

The paper identifies Attractin as the receptor for Nigritoxin, a Vibrio toxin, and shows that related toxins use this receptor but have distinct effector domains.

The paper uses a genome-wide CRISPR screen in Anopheles mosquito cells to identify essential genes and factors involved in clodronate liposome function.

The paper develops bioinformatic and cell-based tools for pooled CRISPR knockout screening in mosquito cell lines to study gene function and disease control.

The paper develops CRISPR tools and site-directed transgenesis in Culex mosquitoes to improve gene drive systems for disease control.