Grit Bornschein

Loose coupling between Ca2+ channels and release sensors as a synaptic correlate of higher order brain function

The paper identifies differences in synaptic nanoarchitectures between prefrontal and somatosensory cortices, linking loose coupling to higher order brain functions.

Red fluorescent labeling of myelin by membrane-targeted tdTomato in transgenic mouse lines

The paper develops transgenic mouse lines with red fluorescent labeling of myelin, enabling structural and functional imaging compatible with green spectral sensors.

Pyramidal neuron synapses in M2 exhibit properties intermediate between prefrontal cortex and M1 synapses

The paper compares synaptic properties of pyramidal neurons in M2 to those in M1 and PFC, finding M2 synapses exhibit intermediate characteristics between the two.

Estimates of quantal synaptic parameters in light of more complex vesicle pool models

The paper proposes a framework to identify the presence of a series-connected replacement pool in synaptic vesicle dynamics using electrophysiological methods.

The intracellular Ca2+ sensitivity of transmitter release from neocortical boutons

The paper measures the Ca2+ sensitivity of Syt1-triggered release in neocortical synapses and finds it has high affinity and cooperativity.

Fully-primed slowly-recovering vesicles mediate presynaptic LTP at neocortical neurons

This study shows that LTP at layer 5 pyramidal neurons increases synaptic strength by increasing the number of fully-primed, slowly-recovering vesicles.