Johannes Hirrlinger

Red fluorescent labeling of myelin by membrane-targeted tdTomato in transgenic mouse lines

The paper develops transgenic mouse lines with red fluorescent labeling of myelin, enabling structural and functional imaging compatible with green spectral sensors.

Spreading depolarizations exhaust neuronal ATP in a model of cerebral ischemia

This study measures intracellular neuronal ATP changes during spreading depolarizations in cerebral ischemia models, showing ATP depletion under oxygen and glucose deprivation.

After traumatic brain injury oligodendrocytes regain a plastic phenotype and can become astrocytes

This study shows that oligodendrocytes can convert into astrocytes after traumatic brain injury through a transitional AO cell stage, influenced by local environmental cues.

Axo-vascular coupling mediated by oligodendrocytes

The paper demonstrates that oligodendrocytes mediate axo-vascular coupling in the mouse optic nerve by regulating vascular dilation in response to axonal activity.

Myelin lipids as nervous system energy reserves

The paper shows that myelin acts as an energy reserve in the brain under glucose deprivation, supporting oligodendrocytes and axons through fatty acid oxidation.

HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons

This study shows HCN channels modulate action potential velocity and fidelity in central axons through cAMP and neuromodulators, with implications for energy consumption and temporal delays.