Aiman S. Saab

The paper develops transgenic mouse lines with red fluorescent labeling of myelin, enabling structural and functional imaging compatible with green spectral sensors.

PURELIGHT improves photon efficiency and accuracy in fluorescence microscopy by recovering undistorted intensity and lifetime measurements at high count rates across multiple detector technologies.

This paper introduces an in vivo model for focal astrocyte ablation combined with longitudinal two-photon imaging to study CNS responses to astrocyte loss.

The paper shows pial collaterals propagate neurovascular signals between cortical territories, synchronizing blood flow responses beyond activated areas.

The paper shows astrocyte gap junction networks selectively connect specific brain regions and reorganize after sensory deprivation in mice.

This paper introduces a low-cost FPGA-based method to correct pile-up distortions in TCSPC-FLIM, enabling high-speed, accurate in vivo imaging with subcellular resolution.

This study shows that overactivation of prefrontal astrocytes in mice impairs cognition and PV interneuron function through increased kynurenine pathway metabolite KYNA.

The paper identifies monocyte-derived cells as the primary source of ROS-mediated oxidative tissue damage in neuroinflammation, distinct from microglia.

This study investigates the role of oligodendroglia in Wolfram syndrome using mouse models and iPSC-derived cells, finding preserved oligodendroglia function and suggesting alternative targets for treatment.

The paper shows that mature astrocytes can transform into progenitor-like cells to regenerate astrocytic networks after injury in mice.

This study shows that oligodendrocytes use potassium signaling to regulate axonal metabolism and maintain axonal health through metabolic coupling.

The paper shows that myelin acts as an energy reserve in the brain under glucose deprivation, supporting oligodendrocytes and axons through fatty acid oxidation.

This study identifies distinct calcium activity patterns in brain pericyte subtypes, showing differences in dynamics and responses to neuronal activity and extracellular potassium.