Author

Tom Shani

Weizmann Institute of ScienceORCID 0000-0002-4878-2174Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Jacob H. HannaiD· 4 shared Noa NovershterniD· 4 shared Sergey V. Viukov· 4 shared Alejandro Aguilera-CastrejoniD· 3 shared Daoud Sheban· 3 shared Jonathan BayerliD· 3 shared Bernardo OldakiD· 2 shared Emilie Wildschutz· 2 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersDevelopmental Biology

Jacob H. HannaORCID

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4 papers

Recent·Most cited

Transgene-Free Ex Utero Derivation of A Human Post-Implantation Embryo Model Solely from Genetically Unmodified Naive PSCs

Bernardo Oldak, Emilie Wildschutz, Vladyslav Bondarenko, Mehmet-Yunus Comar, Cheng Zhao, Alejandro Aguilera-Castrejon, Shadi Tarazi, Sergey V. Viukov, Thi Xuan Ai Pham, Shahd Ashouokhi, Dmitry Lokshtanov, Francesco Roncato, E. Feldstein Ariel, Max Rose, Nir Livnat, , Jacob H. Hanna

This paper develops a transgene-free human post-implantation embryo model from genetically unmodified naive PSCs, recapitulating key developmental stages and extra-embryonic tissues.

Nature · Sep 6, 2023Peer-reviewedDevelopmental Biology

Human primed and naive PSCs are both competent indifferentiating into bona fide trophoblast stem cells

Sergey V. Viukov, Tom Shani, Jonathan Bayerl, Daoud Sheban, Yonatan Stelzer, Noa Novershtern, Jacob H. Hanna

The paper shows that primed human pluripotent stem cells can be converted into trophoblast stem cells by inhibiting the TGFβ pathway, producing TSCs indistinguishable from those derived from placenta or naive PSCs.

bioRxiv · May 20, 2022 · PreprintDevelopmental Biology

Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naive Pluripotency

Jonathan Bayerl, Muneef Ayyash, Tom Shani, Yair S. Manor, Ohad Gafni, Rada Massarwa, Yael Kalma, Alejandro Aguilera-Castrejon, Mirie Zerbib, Hadar Amir, Daoud Sheban, Shay Geula, Nofar Mor, Leehee Weinberger, Segev Naveh‐Tassa, , Jacob H. Hanna

This study identifies signaling pathways that enable the expansion of human naive pluripotent stem cells in defined conditions and highlights differences between mouse and human naive pluripotency.

Cell stem cell · Apr 28, 2021Peer-reviewedDevelopmental Biology

Neutralizing Gatad2a-Chd4-Mbd3 Axis within the NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency

Nofar Mor, Yoach Rais, Daoud Sheban, Shani Peles, Alejandro Aguilera-Castrejon, Asaf Zviran, Dalia Elinger, Sergey V. Viukov, Shay Geula, Vladislav Krupalnik, Mirie Zerbib, Elad Chomsky, Lior Lasman, Tom Shani, Jonathan Bayerl, , Jacob H. Hanna

This study identifies the Gatad2a-Chd4-Mbd3 subcomplex of the NuRD complex as a key inhibitor of naive pluripotency, showing that its disruption enables deterministic reprogramming of somatic cells to iPSCs.

Cell stem cell · Aug 16, 2018Peer-reviewedDevelopmental Biology