Author

Jonathan Bayerl

Weizmann Institute of ScienceORCID 0000-0002-2096-7652Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 3 Research Focus:gene regulatory network inference· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2

Frequent Co-Authors

Daoud Sheban· 4 shared Jacob H. HannaiD· 4 shared Noa NovershterniD· 4 shared Sergey V. Viukov· 4 shared Alejandro Aguilera-CastrejoniD· 3 shared Mirie ZerbibiD· 3 shared Nofar MoriD· 3 shared Rada Massarwa· 3 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersDevelopmental Biology

Daoud Sheban

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Author profile →

6 papers

Recent·Most cited

Decoding the naked mole-rat genome, telomere to telomere

Dustin Sokolowski, Alexander Nater, Mihai Miclăuș, Wenjian Meng, Simon Monis, Wing Yui Ngan, Runjia Qu, Jason Erdmann, Alyssa M. Fontanilla, Vladimir A. Trifonov, DongAhn Yoo, Sana Akhtar Alvi, Alison J. Barker, Odei Barreñada, Jonathan Bayerl, , Gabriel Balmus

The paper presents a telomere-to-telomere genome assembly of the naked mole-rat and compares it with a related species to identify gene losses and duplications associated with unique traits.

bioRxiv · Oct 16, 2026 · PreprintGenomics

An updated reference genome sequence and annotation reveals gene losses and gains underlying naked mole-rat biology

Dustin Sokolowski, Mihai Miclăuș, Alexander Nater, Mariela Faykoo-Martinez, Kendra Hoekzema, Philip C. Zuzarte, Simon Monis, Sana Akhtar Alvi, Jason Erdmann, Archana Lal Erdmann, Kumaragurubaran Rathnakumar, Jonathan Bayerl, DongAhn Yoo, Nadia Karimpour, Kyra Ungerleider, , Michael D. Wilson

The paper presents an updated reference genome for the naked mole-rat, identifying gene losses and gains linked to its unique physiological traits.

bioRxiv · Nov 26, 2024 · PreprintGenomics

Human primed and naive PSCs are both competent indifferentiating into bona fide trophoblast stem cells

Sergey V. Viukov, Tom Shani, Jonathan Bayerl, Daoud Sheban, Yonatan Stelzer, Noa Novershtern, Jacob H. Hanna

The paper shows that primed human pluripotent stem cells can be converted into trophoblast stem cells by inhibiting the TGFβ pathway, producing TSCs indistinguishable from those derived from placenta or naive PSCs.

bioRxiv · May 20, 2022 · PreprintDevelopmental Biology

Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naive Pluripotency

Jonathan Bayerl, Muneef Ayyash, Tom Shani, Yair S. Manor, Ohad Gafni, Rada Massarwa, Yael Kalma, Alejandro Aguilera-Castrejon, Mirie Zerbib, Hadar Amir, Daoud Sheban, Shay Geula, Nofar Mor, Leehee Weinberger, Segev Naveh‐Tassa, , Jacob H. Hanna

This study identifies signaling pathways that enable the expansion of human naive pluripotent stem cells in defined conditions and highlights differences between mouse and human naive pluripotency.

Cell stem cell · Apr 28, 2021Peer-reviewedDevelopmental Biology

Neutralizing Gatad2a-Chd4-Mbd3 Axis within the NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency

Nofar Mor, Yoach Rais, Daoud Sheban, Shani Peles, Alejandro Aguilera-Castrejon, Asaf Zviran, Dalia Elinger, Sergey V. Viukov, Shay Geula, Vladislav Krupalnik, Mirie Zerbib, Elad Chomsky, Lior Lasman, Tom Shani, Jonathan Bayerl, , Jacob H. Hanna

This study identifies the Gatad2a-Chd4-Mbd3 subcomplex of the NuRD complex as a key inhibitor of naive pluripotency, showing that its disruption enables deterministic reprogramming of somatic cells to iPSCs.

Cell stem cell · Aug 16, 2018Peer-reviewedDevelopmental Biology

High-Resolution Dissection of Conducive Reprogramming Trajectory to Ground State Pluripotency

Asaf Zviran, Nofar Mor, Yoach Rais, Hila Gingold, Shani Peles, Elad Chomsky, Sergey V. Viukov, Jason Daniel Buenrostro, Leehee Weinberger, Yair S. Manor, Vladislav Krupalnik, Mirie Zerbib, Hadas Hezroni, Diego Adhemar Jaitin, David Larastiaso, , Jacob H. Hanna

This paper maps high-resolution epigenetic and biosynthetic changes during reprogramming of fibroblasts to iPSCs, identifying two gene modules regulated by different mechanisms.

bioRxiv · Sep 7, 2017 · PreprintDevelopmental Biology