Hao He

The paper identifies driver genes for type 2 diabetes using causal network perturbation analysis and single-cell RNA sequencing in mouse models.

GenomeMUSter integrates and harmonizes mouse genetic variation data across populations to enable multi-trait, multi-population analyses and improve variant-phenotype association studies.

This study maps eQTLs in the striatum of Diversity Outbred mice and provides tools for querying genetic variants and co-expression networks related to striatal gene expression and addiction-related behaviors.

Flaver identifies key transcription factors in ranked gene-lists using weighted rank correlation, outperforming GSEA in 14% of cases and showing experimental support.

The paper identifies genetic loci associated with reversal learning phenotypes in Diversity Outbred mice, revealing a genome-wide significant QTL on chromosome 7.

The paper introduces GBRS, a method to reconstruct diploid genomes and quantify gene expression in multi-parent populations using RNA-Seq data without requiring genotype information.

This study identifies insertion sites in 40 transgenic mouse lines, revealing frequent disruptions of endogenous genes and structural variations.