Ian Mohr

Herpes simplex virus-1 fluidizes the nucleus enabling condensate formation

This study shows HSV-1 protein ICP4 increases nuclear fluidity to enable condensate formation, supporting viral replication.

Transcriptional consequences of herpes simplex virus 1 ICP4 inducible expression in uninfected cells

This study examines how HSV-1 ICP4 expression in uninfected cells alters host gene expression through RNA-Seq, identifying differentially expressed genes and validating findings against infected cell data.

TDP-43 promotes efficient HSV-1 replication in human DRG-derived neurons

This study shows TDP-43 promotes HSV-1 replication in human DRG-derived neurons by enhancing viral mRNA splicing, but not in epithelial cells or fibroblasts.

Topoisomerase 2-dependent nuclear DNA damage shapes extracellular growth factor responses through AKT phosphorylation dynamics to control virus latency

The paper shows that Topoisomerase 2-dependent DNA damage and AKT phosphorylation dynamics regulate HSV-1 latency by integrating extracellular signals and nuclear DNA damage.