The paper identifies distinct progenitor populations in human ganglionic eminences, their gene regulatory networks, and lineage trajectories using single-nucleus transcriptomics and spatial transcriptomics.

bioRxiv · Jan 2, 2026 · PreprintNeuroscience

Single cell analysis of dup15q syndrome reveals developmental and postnatal molecular changes in autism

Yonatan Perez, Dmitry Velmeshev, Li Wang, Matthew L. White, Clara Siebert, Jennifer Baltazar, Guolong Zuo, Juan Moriano, Songcang Chen, David M. Steffen, Natalia Garcia Dutton, Shaohui Wang, Brittney D Wick, Maximilian Haeussler, Stormy J. Chamberlain, , Arnold R. Kriegstein

This study uses single-cell analysis of dup15q syndrome to identify developmental and postnatal molecular changes in autism, revealing cell-type specific dysregulation and shared vulnerabilities with idiopathic ASD.

Nature Communications · Jul 4, 2025Peer-reviewedNeuroscience

Molecular and cellular dynamics of the developing human neocortex at single-cell resolution

Li Wang, Cheng Wang, Juan Moriano, Songcang Chen, Guolong Zuo, Arantxa Cebrián‐Silla, Shaobo Zhang, Tanzila Mukhtar, Shaohui Wang, Mengyi Song, Lilian Gomes de Oliveira, Qiuli Bi, Jonathan J. Augustin, Xinxin Ge, Mercedes F. Paredes, , Arnold R. Kriegstein

This study maps the molecular and cellular dynamics of the developing human neocortex using single-nucleus data, revealing gene regulatory networks and a cancer-related progenitor subtype.

Nature · Jan 8, 2025Peer-reviewedNeuroscience