Author

Tomoaki Takai

Brigham and Women's HospitalORCID 0000-0002-5138-939XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Adam Stuart KibeliD· 1 shared Anne FassliD· 1 shared Baishan JiangiD· 1 shared Celine Pana· 1 shared Fu GuiiD· 1 shared Gary Andrew BradshawiD· 1 shared Jens W. KöllermanniD· 1 shared Jia LiiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Adam Stuart KibelORCID

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1 paper

Recent·Most cited

Acute BRCAness Induction and AR Signaling Blockage through CDK12/7/9 Degradation Enhances PARP Inhibitor Sensitivity in Prostate Cancer

Fu Gui, Baishan Jiang, Jie Jiang, Zhixiang He, Takuya Tsujino, Tomoaki Takai, Seiji Arai, Celine Pana, Jens W. Köllermann, Gary Andrew Bradshaw, Robyn J. Eisert, Marian Kalocsay, Anne Fassl, Steven P. Balk, Adam Stuart Kibel, Jia Li

This paper introduces BSJ-5-63, a PROTAC that degrades CDK12, CDK7, and CDK9, inducing BRCAness and blocking AR signaling to enhance PARP inhibitor sensitivity in prostate cancer.

Science Advances · Apr 23, 2025Peer-reviewedCancer Biology