Sudhir Gopal Tattikota

The paper maps the Drosophila secretome to identify tissue-specific origins and inter-organ trafficking of 535 blood plasma proteins.

MERFISH 2.0 improves transcript detection sensitivity in degraded and archival tissues, enhancing spatial transcriptomic analysis of human and mouse samples.

The paper shows that Drosophila proventriculus cells compensate for age-related cell loss through endocycling rather than stem cell proliferation.

This study develops an optogenetic model of muscle contraction in Drosophila larvae to investigate acute exercise-like responses and identifies transcriptional similarities between fly and human exercise-induced genes.

This paper introduces Haystack, a method to prioritize causal transcription factors from single-cell data, validated in Drosophila, showing high accuracy in identifying drivers of differentiation.

The paper creates a single-cell transcriptomic atlas of the adult fruit fly, identifying over 250 cell types and analyzing gene signatures and sexual dimorphism across tissues.

DRscDB provides a database for comparing scRNA-seq data across species, enabling searches for orthologous genes and cell type-specific expression patterns.

The paper shows that Drosophila muscle-derived Pvf1 signals to hepatocyte-like cells to suppress lipid synthesis and prevent obesity.

The paper uses single-cell RNA sequencing to analyze myeloid blood cell lineages in Drosophila, identifying novel cell types and lineage dynamics during immune responses.

The paper constructs a cell atlas of the adult Drosophila midgut using scRNA-seq, identifying 12 cell types and providing insights into their molecular features and functions.