This study shows that ecDNA mis-segregation leads to micronuclei formation, reduced oncogene transcription, and improved patient survival in neuroblastoma.

bioRxiv · Apr 15, 2025 · PreprintCancer Biology

A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer's disease

Annett Boeddrich, Christian Haenig, Nancy Neuendorf, Eric Blanc, Andranik Ivanov, Marieluise Kirchner, Philipp Schleumann, Irem Bayraktaroğlu, Matthias Richter, Christine Molenda, Anje Sporbert, Martina Zenkner, Sigrid Schnoegl, Christin Suenkel, Luisa‐Sophie Schneider, , Erich E. Wanker

This study identifies Arl8b as a potential biomarker for Alzheimer's disease by analyzing proteomic changes in 5xFAD mouse brain regions and CSF from AD patients.

Genome Medicine · Jul 19, 2023Peer-reviewedMolecular Biology

Identification of novel disease relevant genetic modifiers affecting the SHH pathway in the developing brain

Nora Mecklenburg, Izabela Kowalczyk, Franziska Witte, Jessica Görne, Alena Laier, Hannes Gonschior, Martin Lehmann, Matthias Richter, Anje Sporbert, Bettina Purfürst, Norbert Hübner, Annette Hammes

The paper identifies Pttg1 and Ulk4 as genetic modifiers that enhance SHH pathway resilience and are involved in primary cilia formation in the neuroepithelium.

bioRxiv · Nov 3, 2020 · PreprintDevelopmental Biology