Author

R. Scott McIsaac

Calico Life SciencesORCID 0000-0002-5339-6032Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2 Genomics· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Organism:yeast· 4 Research Focus:gene regulatory network inference· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:benchmarking· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Griffin Kim· 4 shared Bernd J. WranikiD· 3 shared David G. HendricksoniD· 2 shared Adam Baker· 1 shared Anastasia BaryshnikovaiD· 1 shared Brenda AndrewsiD· 1 shared Charles M. BooneiD· 1 shared Christian A. ShivelyiD· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersSystems Biology

Griffin Kim

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4 papers

Recent·Most cited

A genome-scale yeast library with inducible expression of individual genes

Yuko Arita, Griffin Kim, Zhijian Li, Helena Friesen, Gina M. Turco, Rebecca Y. Wang, Dale Climie, Matej Ušaj, Manuel Hotz, Emily H. Stoops, Anastasia Baryshnikova, Charles M. Boone, David Botstein, Brenda Andrews, R. Scott McIsaac

The paper develops YETI, a yeast library with inducible gene expression, and shows low native expression can bias promoter-perturbing screens.

Molecular Systems Biology · Jun 1, 2021Peer-reviewedSynthetic Biology

MAPPING TRANSCRIPTION FACTOR NETWORKS BY COMPARING TF BINDING LOCATIONS TO TF PERTURBATION RESPONSES

Yiming Kang, Nikhil Patel, Christian A. Shively, Pamela Samantha Recio, Xuhua Chen, Bernd J. Wranik, Griffin Kim, R. Scott McIsaac, Robi David Mitra, Michael R. Brent

The paper improves transcription factor network mapping by combining dual threshold optimization, NetProphet 2.0, and new methods for binding and response data.

Genome Research · Mar 1, 2020Peer-reviewedGenomics

Time-resolved genome-scale profiling reveals a causal expression network

Sean R. Hackett, Edward A. Baltz, Marc Coram, Bernd J. Wranik, Griffin Kim, Adam Baker, Minjie Fan, David G. Hendrickson, Marc Berndl, R. Scott McIsaac

The paper introduces a method to infer genome-wide regulatory causality using time-resolved gene expression data from yeast and validates its predictions experimentally.

Molecular Systems Biology · Mar 1, 2020Peer-reviewedSystems Biology

The Miniature-chemostat Aging Device: A new experimental platform facilitates assessment of the transcriptional and chromatin landscapes of replicatively aging yeast

David G. Hendrickson, Ilya Soifer, Bernd J. Wranik, Griffin Kim, Michael C. Robles, Patrick A. Gibney, R. Scott McIsaac

The paper introduces a new platform to study aging yeast by purifying old cells and analyzing their transcriptional and chromatin changes.

eLife · Oct 18, 2018Peer-reviewedSystems Biology