Sean R. Hackett

A multiomic lifespan signature in genetically diverse, diet-restricted mice

This study identifies molecular changes in diet-restricted mice that correlate with lifespan and aging, highlighting key genes and pathways involved in longevity.

Predicting dynamic expression patterns in budding yeast with a fungal DNA language model

This paper introduces Shorkie, a DNA language model pretrained on fungal genomes that improves gene expression prediction in budding yeast by capturing regulatory motif dynamics and variant effects.

Microbial reaction rate estimation using proteins and proteomes

The paper estimates microbial reaction rates using proteomic data, finding that global proteomes can predict reaction rates with high accuracy without needing detailed mechanistic knowledge.

Automated preparation of plasma lipids, metabolites, and proteins for LC/MS-based analysis of a high-fat diet in mice

The paper describes an automated LLE platform for plasma sample preparation and analyzes metabolomic, lipidomic, and proteomic changes in mice on a high-fat diet.

The Molecular Architecture of Variable Lifespan in Diversity Outbred Mice

The paper analyzes the multiome of Diversity Outbred mice to explore how aging and lifespan are related, finding that proteomic changes correlate with biological age rather than chronological age.

Time-resolved genome-scale profiling reveals a causal expression network

The paper introduces a method to infer genome-wide regulatory causality using time-resolved gene expression data from yeast and validates its predictions experimentally.