Christoph Kaether

Acetylation-dependent remodeling of the secretory pathway shapes the senescence-associated secretome

This study identifies acetylation-dependent remodeling of the secretory pathway in senescence, showing its role in shaping the senescence-associated secretome.

Distinct Effects of Aging and Klotho Deletion on the Choroid Plexus

This study examines how aging and Klotho deletion affect choroid plexus structure and function, finding that Klotho deficiency increases age-related calcification in specific regions.

The microcephaly-associated protein YIPF5 differentially regulates ER-export

This study shows YIPF5 regulates ER export of specific proteins, and its disruption causes neuronal migration defects and microcephaly.

Cell-Type Resolved Protein Atlas of Brain Lysosomes Identifies SLC45A1-Associated Disease as a Lysosomal Disorder

The paper creates a cell-type-specific lysosome protein atlas in the brain, identifies SLC45A1 as a neuron-specific lysosomal protein, and shows its role in lysosomal function and neurodegeneration.

NanTex enables computational multiplexing and phenotyping of organelles across super-resolution modalities

NanTex enables multiplexing and phenotyping of organelles using nanotexture descriptors from single-channel super-resolution microscopy data across multiple modalities.

Conserved exchange of paralog proteins during neuronal differentiation

The paper identifies conserved paralog substitutions during neuronal differentiation across species and shows their impact on neuron development.