William Durso

This study shows YIPF5 regulates ER export of specific proteins, and its disruption causes neuronal migration defects and microcephaly.

The paper creates a cell-type-specific lysosome protein atlas in the brain, identifies SLC45A1 as a neuron-specific lysosomal protein, and shows its role in lysosomal function and neurodegeneration.

NanTex enables multiplexing and phenotyping of organelles using nanotexture descriptors from single-channel super-resolution microscopy data across multiple modalities.

This study investigates changes in the synaptic proteome and transcriptome during aging, revealing decoupling between transcripts and proteins and altered ribosomal gene distribution.